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Generic Norvasc Chemical Name: AMLODIPINE Common uses Norvasc (AMLODIPINE) is a calcium channel blocker used to control high blood pressure or angina (chest pain). Reducing high blood pressure helps prevent strokes, heart attacks and kidney problems.

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Amlodipine valsartan cost effective therapy for high blood pressure (HD) as compared with conventional drug class therapy in patients with hypertension (HTN) the presence of renal insufficiency has been evaluated with a 3-year follow-up study at 1 of 3 sites SAVYTEK and the Janssen Diabetes Care Center. In this multicenter, open-label trial, SAVYTEK (200 mg daily, 10 intravenously in divided doses) was administered to patients aged 40 74 years with a baseline total systolic blood pressure (TPB) ≥160 mm Hg (susceptibility), and had a mean baseline HbA1C (HbA1C%) of 7.5%. Patients with HTN (HTN-IRP, 7.3-7.5%) were enrolled. SAVYTEK 100 mg/day was discontinued after 3 years with a total of 362 patients followed. SAVYTEK was associated with a significant reduction in both the annualized rate (ARR) and mean TPR from baseline to 3 y of follow-up compared with conventional drug therapy in patients treated with SAVYTEK. SAVYTEK reduced the HbA1C by −0.07 to −0.10% (P = 0.01) compared with conventional drug therapy, but the HbA1C was significantly lower among the HTN patients compared with HbA1C–nonhypertensive (0.11% vs. 0.28%, P<0.001). SAVYTEK was associated with a significant reduction in the ARR (−0.24% to 0.03%, P = 0.02) and median ARR (0.09% vs. 0.27%, P < 0.001) compared with conventional drug therapy in HTN patients. SAVYTEK was not recommended for patients taking the NPH–insulin with its associated risk of increased HbA1C from 6.0% to 7.0%. SAVYTEK is an effective and well tolerated medication with good tolerability during treatment. These data indicate that an effective and well tolerated drug with good tolerability, which is effective in reducing both the rate and mean HbA1C in HTN patients, is worth considering as an option for the treatment of HTN. The U.S. Senate confirmed a record number of Trump nominations Tuesday, setting up a potentially messy confirmation battle for his Supreme Court pick. The Senate confirmed nine of President Donald Trump's 14 picks to federal courts or the executive branch Wednesday, setting stage for a contentious confirmation fight. At least two vacancies on the D.C. Circuit Court of Appeals, known as the second most powerful court in the country with its jurisdiction extending well beyond D.C., remain unfilled amid opposition from Republicans and Democrats. Four nominees to the National Labor Relations Board remain unconfirmed, including acting Chairman Mark Gaston Pearce, a California Democrat who has been a proponent of expanding labor rights. Three the vacancies are likely to be filled by Trump nominees, including the Labor Department's top civil rights official, Thomas Perez, the Obama administration's first Hispanic appointee to the agency. Trump administration is in the midst of nominating two more Hispanic employees at the Justice Department. A seventh vacancy, on the U.S. District Court for Eastern of Texas, was also vacated Tuesday when a judge on the court, Dallas-based John L. Kane Jr.

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